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What is multiple myeloma, and how is it treated?

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(@komal)
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What is multiple myeloma, and how is it treated?
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Multiple myeloma is a type of cancer that affects plasma cells, a type of white blood cell found in the bone marrow. In multiple myeloma, abnormal plasma cells grow uncontrollably, crowding out healthy blood cells and producing abnormal proteins called monoclonal proteins or M proteins. This can lead to weakened bones, low blood counts, kidney damage, and other complications.

Treatment for multiple myeloma depends on factors such as the stage of the disease, overall health, and individual preferences. Common treatments include:

Chemotherapy: Chemotherapy drugs are used to kill cancer cells or slow their growth. Different combinations of chemotherapy drugs may be used depending on the patient's response to treatment and the stage of the disease.

Targeted Therapy: Targeted therapy drugs target specific molecules or pathways involved in cancer growth and survival. Drugs like proteasome inhibitors (e.g., bortezomib, carfilzomib) and immunomodulatory drugs (e.g., lenalidomide, pomalidomide) are commonly used in the treatment of multiple myeloma.

Immunotherapy: Immunotherapy drugs, such as monoclonal antibodies (e.g., daratumumab, elotuzumab), help the immune system recognize and attack cancer cells more effectively.

Stem Cell Transplantation: Stem cell transplantation, also known as bone marrow transplantation, may be considered for eligible patients. It involves replacing diseased bone marrow with healthy stem cells collected from the patient (autologous transplant) or a donor (allogeneic transplant).

Steroids: Steroid medications, such as dexamethasone or prednisone, may be used to reduce inflammation, control symptoms, and improve treatment outcomes.

Supportive Care: Supportive care measures, such as bisphosphonates to strengthen bones, blood transfusions to improve low blood counts, and medications to protect the kidneys, may be used to manage symptoms and complications associated with multiple myeloma.

Treatment plans are individualized based on the patient's specific needs and may involve a combination of these approaches. Regular monitoring, follow-up appointments, and adjustments to treatment are important for managing multiple myeloma and optimizing outcomes.

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