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Can HPV vaccination prevent cervical cancer?

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(@komal)
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Can HPV vaccination prevent cervical cancer?
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(@rohini)
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Yes, HPV vaccination can effectively prevent cervical cancer by protecting against infection with the high-risk strains of human papillomavirus (HPV) that cause most cases of cervical cancer. HPV vaccines are highly effective in preventing infection with HPV types 16 and 18, which are responsible for approximately 70% of cervical cancer cases worldwide.

Here's how HPV vaccination helps prevent cervical cancer:

Protection Against High-Risk HPV Strains: HPV vaccines, such as Gardasil 9 and Cervarix, provide protection against the most common high-risk HPV strains, including types 16 and 18. These vaccines stimulate the immune system to produce antibodies that prevent infection with these HPV strains.

Prevention of Precancerous Changes: HPV infection can cause changes in cervical cells that may lead to precancerous lesions or dysplasia. By preventing infection with high-risk HPV strains, HPV vaccination reduces the risk of developing precancerous changes in the cervix, which can progress to cervical cancer if left untreated.

Reduction in Cervical Cancer Incidence: Studies have shown that HPV vaccination significantly reduces the incidence of cervical cancer and precancerous lesions in vaccinated populations. Vaccination programs have led to substantial declines in HPV infection rates and cervical cancer incidence in countries with high vaccination coverage.

Long-Term Protection: HPV vaccines provide long-lasting protection against HPV infection and associated diseases. Clinical trials have demonstrated that HPV vaccines offer high levels of protection against HPV-related diseases for at least 10 years following vaccination, with evidence suggesting that protection may persist even longer.

Prevention of Other HPV-Related Cancers: In addition to cervical cancer, HPV vaccination can also prevent other HPV-related cancers, including vulvar, vaginal, anal, penile, and oropharyngeal (throat) cancers. Vaccination against HPV reduces the overall burden of HPV-related diseases and cancers.

HPV vaccination is recommended for adolescents and young adults, ideally before they become sexually active, to maximize its effectiveness in preventing HPV infection and associated diseases. Vaccination is typically administered in two or three doses over several months, depending on the vaccine type and age at vaccination. By increasing HPV vaccination coverage and ensuring access to vaccination for all eligible individuals, it is possible to further reduce the incidence of cervical cancer and other HPV-related diseases.

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